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Effect of use Diazepam

Diazepam affects the part of the human brain that has a significant part in sensation and well-being: the limbic system. It reduces the excitability of cells in the brain by preventing the release of neurotransmitters and thus dampens the limbic system. As a result, external and also internal stimuli are perceived much more weakly and processing takes place in a lighter form and, for the user, with greater emotional distance. Here, diazepam has a calming, antianxiety and antispasmodic effect in particular, and relaxes the muscles. It also has a sleep-inducing effect. The user is thus emotionally calmed. At the same time, vital functions continue to function unimpaired, so that the heartbeat, respiration and blood pressure normalize and the organism regains its composure.

Indications for use

Indications for the use of diazepam include the following disorders:

  • Anxiety disorders
  • falling asleep and sleeping disorders
  • epilepsy or other seizures
  • alcohol withdrawal syndrome
  • acute or chronic states of anxiety, tension or excitement
  • vegetative dystonia, i.e. a disturbance in the conduction of excitation in the autonomic nervous system, which is responsible for heartbeat, blooli pressure, breathing and digestion

  • spasticity

In addition, diazepam is also given as a premedication before surgical or diagnostic procedures to calm and sedate the patient.

In so-called status epilepticus, i.e., when a seizure lasts for an exceptional length of time or when several seizure events occur in quick succession, diazepam is the first drug of choice. In these cases, it is usually administered via venous access.

Intake and dosage Valium

Diazepam is taken and dosed after strict medical consultation, as the drug is a prescription medication.

Diazepam is available in oral dosage form as tablets or drops. It is also available as a suppository and a rectal tube. In this case, the suppository is inserted into the anus and the contents of the tube are emptied into the rectum. Application via intravenous access is also possible.

The attending physician decides on the dosage and duration of use. As a rule of thumb, the dose and duration of use are kept as low as possible. As a rule, the use of diazepam should not exceed a period of four weeks.

The drug should not be taken after meals, as the onset of action can be significantly delayed by a full stomach. Therefore, it is recommended to take it before meals.

If the use of diazepam is no longer necessary, the drug should not be stopped suddenly, but rather phased out. This means that the dose and frequency of use are gradually reduced until use is no longer necessary.


Side effects of Diazepam

The occurrence of side effects happens mainly at the beginning of taking the drug, that is, in the first few days. The side effects of diazepam include mainly:

  • Daytime sleepiness and drowsiness
  • Impaired attention
  • impaired responsiveness
  • drowsiness and dizziness
  • confusion and temporary memory lapses
  • headaches
  • disturbances of movement and gait
  • Enhancement of depressive mood in depressed patients
  • sensory disturbances
  • paradoxical effect, i.e. reversal of the actual mode of action, including states of agitation, restlessness and anxiety, insomnia or suicidali thoughts

Decrease of the effect when taken over a longer period of time.

Prolonged use of higher doses of diazepam may also result in impaired speech clarity and speed, and visual disturbances are also possible. In the case of long-term medication, unsteady gait and movement may also occur.

Are interactions possible when taking diazepam and other active ingredients?

Interactions may occur when taking diazepam and the following active ingredients and medicines:

  • Alcohol: unpredictable, usually marked enhancement of the effect of diazepam.
  • Muscle relaxants: enhancement of the muscle relaxant effect
  • anticonvulsants: possible reduction in duration of action of diazepam
  • centrally depressant drugs: potentiation of drowsiness, possible reduction of respiratory rate
  • Grapefruit juice: inhibition of absorption of diazepam via the intestine and thus reduction of effect.

When should diazepam not be taken?

As with all medications, diazepam should not be taken if there is hypersensitivity or allergy to the active ingredient. Also, in cases of severe pathological muscle weakness, the use of diazepam is not indicated under any circumstances.

In other cases requiring rapid emergency treatment, the exact weighing of benefits and risks should be assessed by a physician.

What is diazepam?

Diazepam (5 mg / 10 mg) is a sedative and refers to drugs of the group of benzodiazepines. It is widely used in medicine to treat alcohol dependence and other pathologies. Its properties allow you to calm the nervous system, relieve anxiety and tremors, eliminate pain caused by muscle spasms.

Form release and active ingredient

The active ingredient of the drug has the same international name Diazepam (INN). Absolute analogues can be sold under other names, the most popular ones are: Relanium, Valium, Sibazon, Seduksen.

The drug is produced in the following forms:

Tablets of 5 and 10 mg for internal use. They have a rounded shape and white color. In some manufacturers the color is different (tablets are blue, pink or another color). Act after 20-40 minutes, before reaching the brain, they are partially neutralized by the liver.


After ingestion, 75% of the drug enters the blood, with the remainder passing through the liver. The greatest level of the drug in the body is observed after 60-90 minutes. Intravenous administration allows the drug to act almost immediately and completely. To maintain the effect of a constant concentration, diazepam should be taken for 5-7 days.

Effect Diazepam on the body

The mechanism of action of diazepam is to stimulate benzodiazepine receptors with simultaneous activation of GABA receptors and inhibition of synapses that regulate the emotional sphere, including thalamus, hypothalamus, reticular formation and the limbic system of the brain. Thanks to this action, when using diazepam, several effects can be achieved simultaneously. Its ability to regulate the central nervous system provides such results:

Sedative. The calming effect is to relieve anxiety and fear, reduce the reactivity of the body to external stimuli, drowsiness. If you use the drug in the maximum amount, it may cause inability to concentrate and scattering of attention. Overdose causes amnesia.

Anxiolytic. A person decreases the level of anxiety, fears and tension go away.

Sleeping pill. Inhibition of arousal in the brain and elimination of excessive arousal helps a person normalize sleep and ensures rapid falling asleep.

Anticonvulsant. The muscle relaxation effect of the substance blocks the implementation of an impulse by the insertion neurons located in the spinal cord. This allows you to stop seizures and reduce limb tremors.

The drug helps to increase the pain threshold, reduces the need for peripheral tissues of oxygen, eliminates syndromes caused by the activation of the autonomic nervous system. All the main effects of Diazepam 10 mg work favorably during the treatment of chronic alcoholism. It makes it much easier to survive the signs of abstinence by stopping most of its symptoms. Drug helps to reduce trembling of hands, restlessness, anxiety, unmotivated aggression, the convulsive syndrome and reduces the severity of the signs of delirium tremens.

Indications for the use of diazepam

To achieve the desired result, you must take the drug according to the prescribed instructions. Do not use the drug without the advice of a doctor, as Diazepam causes many negative effects and leads to dependence.

Recommended dosages

According to the instructions, the dosage of Valium for an adult is 4 to 15 mg per day. Take the drug is necessary by dividing the total dose into two doses. Parenteral administration is carried out from 10-20 mg, and its diversity is determined by a specialist. The withdrawal syndrome is stopped by using a sedative of 10 mg to 4 times a day. After that it is recommended to change to a maintenance dose of 5 mg 2-4 times a day.


The drug has many side effects. And in some cases its use is contraindicated. Diazepam 5 mg is not recommended for treatment in such situations and diseases:

  • glaucoma without fluid drainage (narrow-angled);
  • functional insufficiency of kidneys and liver;
  • respiratory diseases;
  • muscle fatigue;
  • severe pressure drop; shock;
  • fainting;
  • organic changes of the brain;
  • drug overdose and alcohol intoxication.
  • Side effect

Before you start treatment you should read the instructions carefully. Some patients when using Valium may feel its side effects:

  • Marked drowsiness;
  • Weakness, lack of activity;
  • Myasthenia;
  • Bronchospasm;
  • Drop in blood pressure;
  • Hiccups (with rapid intravenous administration);
  • Dry mouth;
  • Respiratory disturbance;
  • Decreased potency in men (goes away after stopping the drug);
  • Paradoxical agitation;
  • Nausea, vomiting, and bowel disorders;
  • Hyperprolactinemia.

In case of negative symptoms or intolerance after taking or administering the medication you should immediately consult a doctor. It may be necessary to decrease the dose or reconsider treatment in favor of another sedative.

Interactions with alcohol and other medications

The treatment cannot be combined with alcohol under any circumstances. If you take strong drinks at the same time with Diazepam 10mg, the probability of an adverse reaction increases significantly even at minimal dosage. Intoxication occurs more quickly, pronounced inhibition of brain structures leads to unconsciousness and a life-threatening condition.

During the use of the drug it is necessary to take into account the features of its interaction with other drugs. Otherwise, the symptoms of overdose and negative reactions may be increased or drastically reduced:

  • the probability of side effects increases when using anticoagulants and beta-blockers;
  • the use of sleeping pills increases drowsiness and slowing down;
  • the use of muscle relaxants may cause severe weakness and potentiation of the sedatives effect joint treatment with neuroleptics increases theili effectiveness;

  • taking antidepressants levels the effect of anxiolytics.

The mechanism of action of Valium is to reduce the excitability of nerve cells. It helps to stop all major signs, eliminates:

  • Arousal;
  • Psychomotor agitation;
  • Sleep disturbance.

The drug helps to increase the pain threshold, reduces the need of peripheral tissues for oxygen, removes syndromes caused by the activation of the autonomic nervous system. All the main effects of diazepam work favorably during the treatment of chronic alcoholism. It makes it much easier to survive the signs of abstinence by stopping most of their symptoms. The drug eliminates trembling of hands, unmotivated aggression, convulsive syndrome, hallucinosis.

In acute psychotic manifestations of an alcoholic during withdrawal, the drug is best administered intravenously or intramuscularly. This allows the problem to be resolved quickly. At home, it is recommended to use rectal administration. It is not always appropriate to take, especially if nausea and vomiting occur.

It is the first remedy recommended to remove the signs of delirium. Therefore, its use is considered normal practice and gives good results. If a person takes alcohol during treatment, it is possible to increase the state of intoxication. Pronounced inhibition of central mechanisms can lead to respiratory depression and unconsciousness. And at high doses of the drug, a fatal outcome cannot be ruled out.

Overdose using Diazepam

If you exceed the amount of the drug used or use it in violation of the liver and kidneys, overdose of diazepam (5mg) may occur. It manifests itself by such symptoms:

  • Severe suppression of the nervous system of various degrees. This may be a pronounced drowsiness, lethargy, inhibition, and even a comatosli state.

  • Muscle weakness, atonia, ataxia.
  • Suppression of reflexes, confused consciousness.
  • Drop in blood pressure.
  • Violation of respiratory function.
  • Treatment of this condition is carried out in a resuscitation hospital for the possibility of constant control of vital functions.
  • Recommendations

Precautions should be observed during treatment with Valium. Experts recommend:

Do not use it as a monopreparation when anxiety is combined with depression. In this case, there is a high probability of a suicide attempt.

Take into account the drugs ability to cause paradoxical reactions with pronounced agitation and aggression. For this reason, do not use it in people with behavioral abnormalities.

When appointing understand that the drug has no effect on people who are in a state of affect and does not help in the development of productive symptoms with mental abnormalities.

Do not take people while driving and at work, which requires rapid response and increased attention.

If you need long-term use of Valium, it is important to constantly monitor liver function and take peripheral blood analysis during this time.

In the event that anxiety and tension are not associated with alcohol withdrawal syndrome, but manifest during an unexpected or regular stressful situation, the use of the sedative will not have the desired therapeutic effect.

In elderly people, the drug is taken with caution and under the control of the condition. At this age, the minimum dosage may lead to accumulation of the active substance.

Buy Diazepam (Valium) online

  • Diazepam belongs to the benzodiazepines.
  • It reduces anxiety and has a calming and muscle relaxant effect.
  • Doctors prescribe diazepam for anxiety, insomnia and epilepsy, among other things.
  • You can also use it for muscle spasms and alcohol withdrawal symptoms.
  • Diazepam is available as tablets of 2 mg, 5 mg and 10 mg.
  • The doctor can also administer it by injection. It is also available as an enema.
  • Side effects include flattened emotions, fatigue and confusion.
  • Do not drink grapefruit juice while taking diazepam. This increases the risk of side effects.
  • Diazepam is known under the brand names Valium and Stesolid.

Effects of diazepam

Diazepam - formerly known to many under the brand name Valium - belongs to the benzodiazepines. It reduces anxiety, has a calming effect and relaxes muscles. Diazepam has a long-lasting effect. Half to one and a half hours after ingestion, diazepam attaches to special receptors in the central nervous system. The drug remains effective for over 12 to 24 hours. It causes you to become calmer and sleepy. Doctors prescribe diazepam for a variety of conditions, some of which we discuss below.

Diazepam for anxiety

Anxiety is a natural reaction when faced with danger. Some people have anxiety more often than usual. For example, you might be afraid of public places, social encounters, or be overcome by fear at unexpected times. Diazepam has a calming effect when you are anxious or tense. Physical symptoms, such as heart palpitations and tremors also reduce.

Diazepam for insomnia

Insomnia is when you have trouble falling asleep, wake up often and/or wake up too early and cannot function well during the day. It causes fatigue, difficulty concentrating and irritability during the day. With insomnia, the symptoms are present more than three nights a week and longer than three months. Diazepam makes you calmer and sleepier. You fall asleep easier and wake up less often.

Diazepam for muscle spasms

Muscle spasms are involuntary (continuous) muscle contractions. Muscle spasms usually occur after exercise. The muscles become hard and it is difficult to relax. The doctor may prescribe diazepam to relax the muscles. The cramping disappears and pain symptoms decrease.

Diazepam for epileptic seizure

During an epileptic seizure, a kind of short circuit occurs in the brain. There is a temporary disruption of electrical stimulus transmission in the brain. This is sometimes accompanied by muscle twitches and short-term unconsciousness. With a severe and long lasting epileptic seizure, it is important to stop the seizure. This can be done with a diazepam enema or injection.

Diazepam in alcohol withdrawal

Alcohol withdrawal occurs when you greatly reduce or stop excessive alcohol consumption. Symptoms such as sweating, insomnia, anxiety and irritability are common. The doctor may prescribe diazepam to reduce withdrawal symptoms. After taking it, the muscles relax and you become calmer. Anxiety and panic attacks decrease.

Note: The doctor may also prescribe diazepam for other conditions. Use the medicine only if the doctor prescribes it.

Side effects of diazepam

Frequently asked questions about Valium

View answers to frequently asked questions about Valium here. Can you combine this medicine with other drugs? And what should you watch out for when using Valium? Have a quick look to see if the answer to your question is listed here.

Diazepam and alcohol

Do not drink alcohol when you use diazepam. Diazepam has a calming and relaxing effect. A side effect of diazepam is drowsiness and decreased responsiveness. Alcohol can increase the sedative effect. It can make you very sleepy.

What is the duration of action of 5 mg diazepam?

The duration of action of diazepam is long. After taking the tablet, within half an hour you will feel the calming and relaxing effect of the medicine. The effect lasts for a good 12 to 24 hours. It takes more than a week for diazepam to completely disappear from the body.

Can you buy diazepam on your own?

You cant buy diazepam on your own. Buying diazepam online is not recommended. Use the medicine only if the doctor prescribes it. At the pharmacy, diazepam is available under the following brand names: Diazepam, Diazepamum, Diazemuls. Diazepam is known to many people by the names Stesolid and Valium.

How does diazepam work in conjunction with other medications?

I have asthma due to stresses. Therefore, I want to take diazepam now. I am also reducing rivotril from 3 to 1 tablet of 2 mg. Would using the diazepam help me to cut down on the medications for asthma? Bricanyl I just forget because I am so much calmer. Could symbicort twice daily and singulair of 10 mg then go away?

The medication you are taking, tensions alone are not the cause of your asthma. Both symbicort and singulair are drugs that suppress the inflammation that plays a role in asthma. Both drugs have little to no effect in exertional asthma. It is likely then that there is an inflammatory component for which you are being treated, and the medication used for this should be taken continuously. If you inhibit the stresses by taking a diazepam, the inflammation will remain and it is not the case that you will no longer need to take the symbicort and singulair. Whether it makes sense to start taking diazepam in addition, I also wonder, because you are already taking a benzodizepine (rivotril), which you now want to phase out. Your plan is to replace one benzodiazepine with another. I dont see the point in doing this and would advise against it. If the rivotril does not have enough effect, diazepam will not be the solution. (HK)

How can I distinguish fake diazepam from the real thing?

It is common knowledge that a lot of bad drugs are sold on the Internet. How can you tell the difference between real and fake diazepam?

Diazepam is a drug that, according to the law on drug supply, may only be delivered by a pharmacy upon presentation of a prescription. Only in this way is the safety and composition of this drug guaranteed. If diazepam is obtained in other ways, e.g. via the Internet, this is no longer the case and it is impossible to tell the difference between real and fake.

On the Internet, in addition to illegally obtained real diazepam tablets, counterfeit diazepam tablets are also offered. In both cases, the quality is no longer guaranteed. In the first case, it is not known how the storage, storage conditions and origin are arranged, so that the quality, without laboratory research can not be determined. In the second case, there is a chance that, in the pursuit of profit, people make the tablets themselves using their own procedure and that it is then no longer at all clear what the composition is.

On the face of it, one can not say what real and fake tablets are. There are more than 10 manufacturers in the Netherlands that make real tablets with different prints and sizes. Also illegal manufacturers are able to copy these tablets with the same color, print and size. Therefore, I cannot tell you how to distinguish between real and counterfeit diazepam tablets on the internet, without laboratory testing. (HK)

Dosage of diazepam: 2 mg, 5 mg and 10 mg

The dosage of diazepam varies with each treatment. The drug is available in tablets of 2 mg, 5 mg, and 10 mg diazepam. You can also administer it by injection or rectiole. A rectiole (or enema) is a small tube with an extension that you insert into the anus to administer medication. Find out the usual dosage of diazepam for adults in the table below.

Please note that the above doses are common, but may vary. For children, the dosage is lower. Always stick to the prescribed dosage. This also applies to the treatment of conditions not listed in the table below.

Tapering off diazepam

Dont just stop taking diazepam, but slowly taper off the use if you have been taking the drug for a long time. If you stop suddenly, you may experience withdrawal symptoms, such as anxiety and panic attacks. You may also experience tremors, irritability, and trouble sleeping. Always ask a doctor how you can taper off the use of diazepam, this reduces the chance of symptoms.

What are the symptoms of temazepam poisoning?

What are the symptoms of temazepam poisoning? My ex-husband abroad suffers from thalamus syndrome according to a French specialist, but he himself suspects temazepam poisoning, because he used this drug for a very long time from his childhood and in large doses. I want to help him, by finding data about it.

The symptoms of overdose of temazepam are: severe loss of consciousness to coma, respiratory depression. Prolonged use of doses up to 40mg per day, as a rule, never leads to poisoning symptoms. For this, this dosage should really be many times higher. Poisoning symptoms occur immediately after ingestion of very high doses. Symptoms of poisoning do not occur after the therapy has been discontinued for some time, even if one has taken this drug for many years in a row. (HK)

Order Diazepam

With diazepam you order a benzodiazepine with a relatively long duration of action, which is used primarily in the short-term treatment of anxiety and for the treatment of epileptic seizures, whereby it also has a muscle-relaxing, antispasmodic and sedative effect. It is also frequently used as a sleeping pill. You can order diazepam here. Although it is only available in pharmacies by prescription, we supply diazepam without a prescription.

Order Diazepam: Additional info

The average half-life is about 30 hours. This means that after this time the body has broken down half of the active substance. In older people, the half-life is sometimes higher, up to 80 hours. The dosage depends on various factors and also depends on how well the patient responds to the treatment. The patients age and weight as well as the individual symptoms must be taken into account. The duration of treatment depends on the course of the disease. After two to three weeks, however, the dose should be gradually reduced in order to discontinue the drug. If possible, a longer duration of use should be avoided.